The UCSF Benioff Children’s Hospitals’ Neonatal Cardiovascular Center of Excellence (NCCOE) is a multispecialty, integrated program designed to provide holistic care for premature or critically ill infants with congenital heart disease (CHD). The center monitors and treats at-risk infants in utero through birth and through childhood. The comprehensive nature of the center is designed to improve both survival and long-term cardiovascular and neurodevelopmental outcomes for newborns.