Maria I. Vazquez Roque, M.D., a gastroenterologist at Mayo Clinic's campus in Jacksonville, Florida, discusses non-celiac gluten sensitivity (NCGS). The condition has clinical features that overlap with those of celiac disease and wheat allergy, but the pathophysiologic process in NCGS is thought to be through an innate immune mechanism, whereas celiac disease and wheat allergy are autoimmune- and allergen-mediated, respectively. Dietary triggers other than gluten, such as the fermentable oligosaccharides, disaccharides, monosaccharides and polyols, however, have been implicated. Currently, no clinical biomarker is available to diagnose NCGS and the prevalence of NCGS is unknown.