In their bid to find the best combination of therapies to treat anaplastic thyroid cancer, John A. Copland III, Ph.D., and a team of researchers at Mayo Clinic's campus in Florida demonstrated that all histone deacetylase (HDAC) inhibitors are not created equal.
Dr. Copland discusses the trial of the PPAR-gamma agonist efatutazone combined with paclitaxel, plus newer findings with HDAC inhibitors combined with paclitaxel — a combination therapy not yet in trial.
For more information
Marlow LA, et al. RhoB Upregulation Leads to Either Apoptosis or Cytostasis Through Differential Target Selection. Endocrine-Related Cancer. 2015;22:777.
Clinical trials: Inolitazone Dihydrochloride and Paclitaxel in Treating Patients With Advanced Anaplastic Thyroid Cancer. Mayo Clinic.
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